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Here is how you can figure how much brisket or pulled pork you need to prepare to serve a large crowd. There are several things to consider:
For pulled pork or brisket, a typical sandwich (or serving) is 4 oz of cooked meat.
For adult males, you might want to plan on 2 servings per person.
For women and children, plan on one serving per person.
The average butt loses about 40% of its weight while cooking. Therefore a pound (16 ounces) of uncooked meat will yield 9.6 ounces of cooked meat. 9.6 ounces is 2.4 servings, so every pound of uncooked meat that you start with will yield 2.4 servings.

So, first figure out out many servings you need (2 servings per hungry eater, 1 serving per ordinary eater). Then divide the number of servings by 2.4 servings per pound of uncooked meat and you have the total number of pounds of uncooked meat you need. Here, then, is an example:

10 men and 10 women would require about 30 servings. (2 x 10 men = 20 servings, 1 x 10 women = 10 servings.) Divide 30 servings by 2.4 servings per pound of uncooked meat and you get 12.5 pounds of uncooked meat.
Or from a real-life example:

We were asked to cook pulled pork for a women’s shelter. There were 37 women, but these were 37 hungry women (many took a second sandwich with them after dinner), so we figured 60 servings. 60 divided by 2.4 is 25 pounds of raw meat, which is just about what it took.